Flash Drive

2021 Mercedes E350 4Matic

Model Tested: 2021 Mercedes E350 4Matic Sedan

The 2021 Mercedes E350 sedan is a handsome midsize luxury sedan with an athletic chassis and running gear.

Engine:2.0-liter turbocharged I-4, 250 horsepower 273 lb-ft torque

Transmission: 9-speed automatic, all-wheel-drive

EPA Rating: 22-mpg city, 30-mpg highway, 25-mpg combined

Base Price: $56,750

As Tested: $64,800


Strong acceleration

Very smooth turbo application

The rear 3/4 view is good, too.

Impressive torque for a 2.0-liter I-4

Great long distance driving car

Confident, athletic ride

Exudes engineering excellence

4Matic all-wheel-drive

Excellent safety features


Super stretch-out front legroom

Full power seats including headrest height

Front seat room and comfort are excellent in the E350. The seats are fully power assisted.

Power thigh support

Power lumbar both front seats

Panoramic sunroof (optional) brightens interior

Comfortable rear seat

Good rear knee room if front seats are up slightly

Tall rear floor hump

Wide rear armrest with shallow storage

An adult can fit in middle position

Very thick leather steering wheel

Rear seat comfort is great, too, but the floor hump is quite high.

Lots of auxiliary controls, but small


Power trunk lid

Covered hinges

Wide opening, but 5-6-inch lift over

Flat cargo floor

Big pass through

Split, folding rear seats have significant slope

Huge storage bin beneath floor

High quality trunk carpet

Split, folding rear seats and a flat trunk floor provide good cargo capabilities.

Power, auto folding mirrors

Two stretchy seat back pouches

Medium size console bin

Smallish locking glovebox

WOW Factors:

Great engine, transmission, suspension

Sporty handling

Handsome styling

Extra storage under trunk floor

Very comfy, supportive seats

Voice control

The Mercedes E350 dashboard features an extra wide infotainment screen. The power adjustable steering wheel is very comfortable.


Imitation leather

HVAC controls small, not well marked

We didn’t like the gray ash wood accents

Bottom Line:

The 2021 Mercedes E350 4Matic sedan is an impressive mid-size luxury/sport sedan that exudes the best of what enthusiasts expect from Germanic luxury sedans. The turbocharged four-cylinder engine surprised us with its super smooth power. It felt more like a

Handsome 18-inch alloy wheels cover the powerful four-wheel disc brakes.

big six-cylinder than a 2.0-liter four. There is also a hybrid E350 that makes an incredible 516 lb-ft of torque. The interior is a wonderful combination of support, comfort, and useful high tech infotainment features. It’s a perfect environment for long trips or short errands.